ERCC3 Antikörper (N-Term)

Produktnummer ABIN2780326

Der Kaninchen Polyklonal Anti-ERCC3 Antikörper wurde für WB validiert. Er ist geeignet, ERCC3 in Proben von Human, Ratte, Rind (Kuh), Hund, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen, Schwein und Saccharomyces cerevisiae zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für ERCC3 Antikörper (N-Term) (ABIN2780326)

Target: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen, Schwein, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERCC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ERCC3 Antikörper

Bindungsspezifität: N-Term

Sequenz: MGKRDRADRD KKKSRKRHYE DEEDDEEDAP GNDPQEAVPS AAGKQVDESG

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Human: 100%, Pig: 93%, Rabbit: 79%, Rat: 79%, Yeast: 90%, Zebrafish: 79%

Produktmerkmale: This is a rabbit polyclonal antibody against ERCC3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 782 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ERCC3 Antikörper (ABIN2780326)

Vijai, Topka, Villano, Ravichandran, Maxwell, Maria, Thomas, Gaddam, Lincoln, Kazzaz, Wenz, Carmi, Schrader, Hart, Lipkin, Neuhausen, Walsh, Zhang, Lejbkowicz, Rennert, Stadler, Robson, Weitzel et al.: "A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. ..." in: Cancer discovery, Vol. 6, Issue 11, pp. 1267-1275, (2016) (PubMed).

Details zu ERCC3

Target: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Andere Bezeichnung: ERCC3

Hintergrund: ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription.
Alias Symbols: BTF2, GTF2H, RAD25, TFIIH, XPB
Protein Interaction Partner: XIAP, CEP70, UBC, rev, SRPK2, CDK7, TP53, E2F1, CDK8, CCNC, GTF2H5, ERCC2, MSANTD2, UVSSA, POLR2C, KPNA3, RAD52, MMS19, SIX5, GTF2H4, GTF2H3, GTF2H1, tat, COPS2, GTF2H2, NEDD8, ERCC6, POLR2A, AR, CCNH, MYC, MNAT1, ZSCAN1, ATF7IP, GCN1L1, ERCC5, BCR, PSMC5
Protein Size: 782

Molekulargewicht: 89 kDa

Gen-ID: 2071

NCBI Accession: NM_000122, NP_000113

UniProt: P19447

Pathways: DNA Reparatur